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Choice of Endpoint in Covid Trials

Many trials are now underway to find an effective treatment for COVID-19. To show effectiveness a number of endpoints can be considered – hospitalization duration, ventilator use, and obviously mortality. Is there a preference? In this webinar we will discuss the issue of selection of a suitable endpoints in the context of FDA’s recent guidance, …

Choice of Endpoint in Covid Trials >

Two-sided vs. One-sided Tests: This Should not be “Controversial”

The appropriateness of two-sided vs. one-sided hypothesis tests in clinical trials has been the subject of an old debate.  This is probably because of the intra and inter disciplinary disagreements among statisticians, clinicians and regulators on this matter often expressed via conflicting recommendations in the literature. First let’s look at how the current ICH E9 Guidance …

Two-sided vs. One-sided Tests: This Should not be “Controversial” >

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